By his father's will he inherited the castle of Livadia and the government of the city of Thebes. He supported Theodore I Palaeologus, Despot of Morea, against the Despot of Epirus, Carlo I Tocco. In 1397, he invaded Attica with expansionist intentions. Antonio's career was militaristic and adventuresome. In 1406, he took Staria and in 1410 joined the Ottoman Turks to devastate Venetian Nauplia. In 1419, a peace between the Turks and Venice called on Mehmed I to ask Antonio to cease harassing the Venetians. In 1423, he was at war with Theodore II of Morea and occupied Corinth.