The story follows a reporter named Richard Dees as he follows, attempting to catch up with, a murderer who kills his victims in a vampiristic style. The killer flies to each murder scene in a black Skymaster airplane. At one point, Dees does catch up with the plane and finds dirt inside and the interior covered in blood, heightening the suspense of the film. The plot culminates in Dees' confrontation with 'The Night Flier' and his own loss of sanity.