Wesker City is a city that is run by Albert Wesker and Eve Wesker which is located within Detroit. It is close to New Raccoon City and is usually monitored by Division Delta Codenamed:Anti-Virus. The city is also an area where Miller International produces many of the city's consumer products, military weapons and equipment, even benefitial viruses. The city is also a location where the New World Alliance can meet and discuss new methods of capturing Oswell E. Spencer and his followers.