Megan is Missing is about two teenage girls named Megan Stewart and Amy Herman; Megan is a promiscuous young 14 year old who has a troubled past while Amy is a goody-good girl who's led a rather sheltered life. Somehow, the two girls manage to be best friends. Eventually, Megan begins talking to a guy named Josh online. She tells Amy about him and agrees to meet him. She vanishes after and Amy begins to make a video log about her feelings toward the turn of events. It does not go well.