Keyes was station on the USS Sephora in October 2179 which was sent to investigate the rediscovered USS Sulaco above LV-426. He was part of Rhino 2-3, and was captured by Xenomorphs aboard the Sulaco and impregnated with a Chestburster. Keyes was the last member of Rhino 2-3 alive in the Sulaco's Hive.