In 2371, when the prototype USS Defiant was sent into the Gamma Quadrant, she was equipped with at least one of these shuttlepods. Kira Nerys and Odo used the Shuttle 01 to escape a Jem'Hadar attack. Odo piloted the shuttle to the Founders' homeworld in the Omarion Nebula. In a simulation run by the Vorta, Sisko and Bashir believed they had escaped the battle in a similar craft. (DS9: "The Search, Part I", "The Search, Part II")