Mario is in Rosalina's ship when all of a sudden an orange glob hits the ship and it turn agants her and then Lubba comes and tells them to get on his ship then they go to Bikiki Bottom as SpongeBob and Squidward go to work at the Krusty Krab,then Rosalina's ship shoots something at Lubba's ship and they crash into Bikiki Bottom and Spongebob hears it and goes to see what is wrong then Jimmy Neutron,Cartman,Kyle,Stan,Kenny and the other residents of south park appear and then suddenly ooze droids attack the krusty krab and now everyone has to escape.now they have to defeat the ooze army and go to different worlds,like south park and different mario galaxys and the bikini bottom.