After a series of murders in San Francisco that all take place inside closets, a reporter and his scientist friend decide to uncover the mystery and save California. The film contains many comical and subtle references to homosexuality. The title references the state of being a closeted gay, the creature's sudden smitteness and affection for the handsome leading man even though there is no other indication that the creature is female, and the film ends with it collapsing and dying while "marching on San Francisco."