Star Trek: Darwin comes from the idea of what the reaction would be if Mutants emerged during the Star Trek era. Two years prior to the main story of the fanfic, the Starfleet Officer Anna Marie Adler assigned to the USS Potemkin had her powers emerge, and two years later she is made Captain of the USS Darwin under Admiral Charles Xavier. The story follows the voyages of the Darwin and its mostly Mutant crew under Captain Rogue, trying to keep the Federation safe from other more dangerous Mutants, and keeping Mutantkind safe from those that would persecute them.