German submarine U-166 was a Type IXC U-boat of the Nazi German Kriegsmarine during World War II. The submarine was laid down on 6 December 1940 at the Seebeckwerft (part of Deutsche Schiff- und Maschinenbau AG, Deschimag) at Wesermünde (modern Bremerhaven) as 'werk' 705, launched on 1 November 1941 and commissioned on 23 March 1942 under the command of Oberleutnant zur See Hans-Günther Kuhlmann. After training with the 4th U-boat Flotilla, U-166 was transferred to the 10th U-boat Flotilla for front-line service on 1 June 1942. The U-boat sailed on only two war patrols and sank four ships totalling . She was sunk on 30 July 1942 in Gulf of Mexico.