It is a holiday weekend on Wisteria Lane. Bree and Orson are going on their honeymoon. Gabrielle and Lynette are going a spa vacation. Tom is going on a camping trip with the kids. And Susan is going on a quiet romantic getaway with Ian. But things don't go as planned. Tom calls with an emergency, and Lynette has to go help him. While at the airport, Bree sees Andrew on television featured as a homeless teenager which cuts short her honeymoon. Gabrielle runs into John (special guest star Jesse Metcalfe). And Susan is still insecure about if she's cheating on Mike.