The comic book series featured Neil and his friends Soapy the Cat and Mam'selle Poupée. All three of the characters sing, dance, and play music. The more developed comics stories primarily revolve around the trio's attempts to attain show-business success. While existing as a fantasy with nostalgic style, Neil the Horse also pays tribute to the era it was made (the 1980s). A typical issue included a story in prose with illustrations, a few short comic strips, and a longer comic-strip adventure. As the motto of Neil the Horse was "Making the World Safe for Musical Comedy" all issues also included original sheet music for the songs sung by the characters in the course of their adventures.