USS Weepoose (SP-405) was a United States Navy patrol vessel in commission from 1917 to ca. 1918-1920. Weepoose was built as a private motorboat of the same name in 1911 by the Salisbury Marine Construction Company at Salisbury, Maryland. On 2 July 1917, the U.S. Navy acquired her from her owner, C. S. Thorne, for use as a section patrol vessel during World War I. She was commissioned as USS Weepoose (SP-405) on 22 October 1917. Weepoose was transferred to the United States Department of Agriculture on 28 September 1920.