was a lord of Edo Castle and enemy of the Hōjō clan, who seized the castle in 1524. He was the son of Uesugi Tomoyoshi, who was among the first to oppose the Hōjō's rise to power. In 1524, Tomooki attempted to take the initiative in defending Edo Castle by marching his troops out to meet the Hōjō army in battle. However, his opponent circled around behind the sallying force, taking the castle with the help of Ōta Suketada, the castle keeper who betrayed the Uesugi to the Hōjō. Tomooki also took part in the siege of Arai in 1518, and in the battle of Ozawahara in 1530.