Vanessa is the daughter and only child of Dr. Doofenshmirtz whom he had with Charlene Doofenshmirtz. As badly as he had been abused as a child, Doofenshmirtz cherishes his own daughter dearly and devotes much of himself to trying to make her happy. Vanessa, though mostly unappreciative of this, always understands the trouble her father goes through for her sake in the end.