Ioannis Zisis (, -1941) was a Greek Army general during World War II. Prior to and during the German invasion of Greece, Major General Zisis was commander of the Evros Brigade (Ταξιαρχία Έβρου) deployed in Western Thrace and consisting of 2,100 men. In the Battle of Metaxas Line (April 6–9, 1941), the numerically and technically superior German Army invaded Greece from the Bulgarian border. However, the Greek fortifications at Nymfaia, near Komotini were able to provide a two-day resistance against enemy attacks.