Zachary & Ainsley 5: Spice vs. Blood is a 2013 American computer animated horror drama adventure romantic comedy film directed and written by Tommy Wirkola and produced by David Ellison and Kevin Messick. It stars the voices of Trey Parker, Matt Stone, John DiMaggio, Phil LaMarr, Billy West, Maurice LaMarche, David Herman and Neil Patrick Harris. It is the fifth film in the Zachary & Ainsley film series. It serves as a sequel to Zachary & Ainsley 4: The Sparkly Dance (2012). A sequel, Zachary & Ainsley 6: Signs of Summer, released on June 13, 2014.