Wayne (Bob) Robert Hoffman (December 13, 1917 – April 13, 2005) was a U.S. American football running back in the NFL for the Washington Redskins and Los Angeles Rams. He also played in the All-America Football Conference for the Los Angeles Dons and in the Pacific Coast Professional Football League for the Hollywood Bears. Hoffman was an All-American college football player at the University of Southern California and was drafted in the ninth round of the 1940 NFL Draft.