The Infected Pustules replace the Infected Water Towers from Prototype. When approached, they start to bulge, and if James Heller doesn't destroy them in time, a Brawler emerges from it. Due to the high concentrations of the virus, Heller will gain a significant boost in Evolution points when he destroys a pustule without causing it to release the Brawler. When he destroys the pustule, the Brawler within will be instantly killed.