The squadron was activated on 1 September 1959 as the 22d Air Defense Missile Squadron (BOMARC) and stood alert during the Cold War, equipped with IM-99 (later CIM-10) BOMARC surface to air anitaircraft missiles. The squadron was tied into a Semi-Automatic Ground Environment (SAGE) direction center which could use analog computers to process information from ground radars, picket ships and airborne aircraft to accelerate the display of tracking data at the direction center to quickly direct the missile battery to engage hostile aircraft. The 22d was inactivated on 31 October 1972.