The 2001 Michigan State Spartans football team represented Michigan State University in the 2001 college football season. The Spartans played their home games at Spartan Stadium in East Lansing, Michigan. This was the second year for head coach Bobby Williams, who led the Spartans to a 7–5 record and a 44–35 victory in the 2001 Silicon Valley Football Classic over the Fresno State Bulldogs of the WAC.