USS Pope (DD-225) was a Clemson-class destroyer in the United States Navy during World War II. She was the first ship named for John Pope. Pope was laid down 9 September 1919 and launched 23 March 1920 from William Cramp and Sons; sponsored by Mrs. William S. Benson; and commissioned 27 October 1920 at Philadelphia, Commander Richard S. Galloway in command.