During the events of Mario & Luigi: Partners in Time, Mario, Luigi, Baby Mario, and Baby Luigi confronted the massive Swiggler inside the Vim Factory. In battle, Swiggler could shoot poisonous clouds at the brothers (which could be countered with hammer strikes) and create seismic waves on the ground (which could be dodged by jumping). However, Swiggler would also drink vim and power-up nearby Shroob UFOs. This allowed the flying saucers to shoot energy blasts at Mario and Luigi. Fortunately, the heroic brothers could jump over these blasts to avoid damage.