Mohiam joined the conspiracy to topple the rule of Paul Atreides after he ascended the Golden Lion Throne and unleashed his Jihad upon the Empire. She, along with Scytale (a Tleilaxu Face Dancer), Edric (a Guild Navigator), and Irulan Corrino (embittered wife of Paul Atreides), plotted to insinuate, as the Emperor's Reverend Mother, the Tleilaxu ghola Hayt into the court to weaken Paul's confidence in his prescience and thereby ruin him. When the plot failed, she was executed in the retaliation initiated by Alia Atreides after Paul walked into the desert after the death of Chani, ignoring Paul's instructions that Mohiam be spared.