I-22 was a submarine of the Imperial Japanese Navy which saw service during the Pacific Campaign of World War II. I-22 was commissioned at Yokosuka, Japan on March 10, 1941. The submarine participated in the Battle of the Coral Sea and attack on Sydney Harbour in May and June 1942. I-22 disappeared while on patrol near Malaita in the Solomon Islands on or around October 4, 1942 and was presumed lost with all 100 hands.