According to Ammianus Marcellinus (Res Gestae xx.7.1), in 360 II Flavia Virtutis was stationed in Bezabde with II Armeniaca and II Parthica, when the King of Persia Shapur II sieged and conquered the city, killing many of the inhabitants. According to Notitia Dignitatum (in partibus Occidentis, vii), at the beginning of the 5th century, the comitatensis legion Secundani (very probably II Flavia Virtutis) were under the command of the comes Africae.