HMCS Antigonish was a River-class frigate that served in the Royal Canadian Navy from 1944-1946 and as a Prestonian-class frigate from 1957-1966. Built by Yarrows Ltd., Esquimalt, she was commissioned into the RCN on 4 July 1944 with the pennant K661. She was placed in reserve in 1946 and reactivated in 1947 for use as a training ship until 1954. She underwent conversion to a Prestonian-class frigate in 1956-1957 and was recommissioned with pennant 301 on 12 October 1957. She was paid off by the RCN in December 1966.