He is best known for his work on the Donald Duck comic strip, but he started his career lettering the Mickey Mouse strips (March 1931 – July 1932), and drew the Bucky Bug comics in 1932 as well as Silly Symphonies pages from 1932 to 1939. Taliaferro co-created a number of characters, including Huey, Dewey and Louie, Bolivar, Grandma Duck, and arguably Daisy Duck. He drew Donald Duck comic strips from 1938 until his death in 1969 in Glendale, California.