In a Foldit "de-novo" puzzle, players are given a fixed sequence of amino acids, presented as a straight "extended chain". Unlike design puzzles, which also start with an extended chain, no mutation is allowed on de-novo puzzles. Also unlike a design puzzle, a de-novo puzzle typically has some secondary structures (helixes or sheets) defined. The puzzle comments typically state that the secondary structure predictions are "from PSIPRED". The subject of secondary structure predictions came up in #veteran chat on 8 January 2017 (UTC-6). An edited version of the chat log appears below.