Final Flight of the Osiris was written by the Wachowski Brothers and directed by Andy Jones, with CG-animation production and design by Square's North American division. The film was produced by the same animation company that created the film Final Fantasy: The Spirits Within, which also utilized photo-realistic CGI characters, although the realism level was increased for the characters in this short film. Production of Final Flight of the Osiris, according to comments on the Animatrix DVD release, occurred immediately following production of the Final Fantasy film. This film was one of the last produced by Square Pictures before the box office failure of Final Fantasy: The Spirits Within.