Syntho-surfactant was a synthetic treatment for plasma burns. Shortly after Commander Charles Tucker III ignited a plasma explosion aboard Enterprise NX-01, Doctor Phlox treated him with syntho-surfactant in the starship's sickbay. At one point, Phlox urgently ordered a medical crewman to add two percent syntho-surfactant in an (ultimately unsuccessful) attempt to treat Tucker's lungs, which had been thermalized by the super-heated plasma. (ENT: "These Are the Voyages...")