The Splicers in Burial at Sea are precursors to the later ADAM-mutated, war-scarred enemies faced by Jack, Subject Delta, and Subject Sigma. These Splicers have been locked up in Fontaine's Department Store, and many have already lost their sanity. Their manic craving for ADAM has them seeking the few remaining drinkable Plasmids. They also suffer from injuries they received from fighting both against the Rapture authorities and among themselves.