The titular method is a scientific procedure to exterminate screwflies by causing them to become murderously aggressive towards the females of the species when aroused. It's brought up to a far more disturbing level when men all over the world begin acting in a similar manner. The main protagonist Anne Alstein tries to save her daughter during the onslaught but loses her to her affected husband Alan. During the onslaught, a new religious movement composed entirely of male Christians called the Sons of Adam is spreading along with the murders, and they believe that women are evil, that the Garden of Eden was a paradise with the first man Adam living alone in a state of innocence and bliss before the birth of the first woman Eve, and that God is telling them to get rid of all of the women. W