The Mamemame Laboratory looks like a large, tall blue rectangular building. There is a large clear sphere on top of the building with a decoration that looks like a Tamagotchi head inside. There are four large screws on the front of building. A fence surrounds the entire building and nearby area, Originally, official artwork depicted the building as being mostly blue and yellow, and sitting on top of a large hill. In the anime, the building appears to be mostly blue and purple, and is on flat ground.