Cletus and Brandine Spuckler's children are sorted by appearance: Though in "Changing of the Guardian", Brandine says that they have 70 children. It's possible that their large amount is probably due to adoption, boost, abducting or illusion either from the couples's or their neighbors's mental status, for their so-called biological mother Brandine is of young age, and women in reality has a limit of birth. Also, their nature of being product of incest is probably a joke or a result of misunderstanding of their parents's sexual roleplay.