While in New Orleans on vacation with her good friend Bess, Nancy goes to check up on Ned's friend, Henry Bolet, Jr in his late uncle's mansion. As soon as she arrives, she encounters a couple of interesting and odd characters, and has to stay at the house because of a bad storm. Once she finds out that Henry Bolet is less than stable after his uncle's death, and there are seemingly sinister things going on in the house, Nancy becomes entangled in a mystery. There are multiple places to explore and visit, including a graveyard on the grounds of the mansion, a bizarre oddities shop, and a gumbo stand. Nancy and Bess work together in order to untangle the mystery of the Crystal Skull.