Most of this protein is shown in grey, meaning it's locked and can't be moved. The first step is to select Design Mode from Modes menu. Now the two orange segments can be "mutated", meaning you can change the amino acid. In Design Mode, click on one of the orange segments. The Mutate wheel menu appears. The outer ring of the mutate wheel has the hydrophobic amino acids, and the inner ring has the hydrophilic ones. In this puzzle, only the shake tool is available, wiggle is not there. Try picking different amino acids for each of the two segments, then shake and see what happens.