The program is made up of three segments: "Dial 'M' for Murder (or Press # to Return to Main Menu)", "Don't Have a Cow, Mankind" and "There's No Business Like Moe Business". The plot of the first segment is based on the 1951 Alfred Hitchcock movie Strangers on a Train and contains several references to other Hitchcock films. The second segment is a parody of 28 Days Later and other zombie movies. The third segment spoofs the musical Sweeney Todd.