Simon II of Isenburg-Kempenich was the Lord of Isenburg-Kempenich from 1341 until 1367. Simon II was the eldest son of Simon I, and succeeded him on his death in 1341. In 1345 the Archbishop of Trier Baldwin of Luxembourg decreed that the Lordship of Kempenich and all its territories were indivisible and the sole property of the lord, and Simon's brother John signed an agreement. Simon died in 1367 and, despite the document, was succeeded by his four sons: Simon III, Theodoric VI, John, and Henry.