The Agasha Alchemist, also known as Agasha Ikakeya, were alchemists who learned how the elements combine in different forms in nature, creating the Mizugusuri, Kagaku, and other technical arts. They used the bubun language to help to describe how the elements were part of all things, animate or inanimate. The Isawa disapproved of such research and much of this was abandoned when the Agasha defected to the Phoenix Clan.
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