The 2008 Ole Miss Rebels football team represented the University of Mississippi during the 2008 college football season. The team's head coach was Houston Nutt, who served his first season in the position and replaced Ed Orgeron, who was fired after accumulating a 10–25 record (3–21 conference) at Ole Miss from 2005–2007. The Rebels played their seven home games in 2008 at Vaught-Hemingway Stadium in Oxford, Mississippi.