This type of game over happens to new (or careless) players. Even so, this is by far the rarest way to lose the game. Happens when the whole family (including the Presidente) dies or disappears suddenly. Dynasty members can run away or be "retired". The Presidente can not retire (unless there is another dynasty member), but he can be killed (the only known time this could happen if the Presidente decides to use the fake war with the US for a change in leadership).