USS O-16 (SS-77) was an O-class submarine of the United States Navy. Her keel was laid down on 7 October 1916 by California Shipbuilding Company in Long Beach, California. The later O-boats (O-11 through O-16) were designed by Lake Torpedo Boat to different specifications from the earlier ones designed by Electric Boat. They performed much less well, and are sometimes considered a separate class. O-16 was launched on 9 February 1918 sponsored by Mrs. I. H. Mayfield, and commissioned on 1 August 1918 with Lieutenant W. M. Quigley in command.