Maria Santiago (née Flores) was the wife of Dom. She was a childhood friend of the Santiagos and Marcus Fenix, and she would later date and marry Dominic Santiago, shortly before giving birth to their first child, Benedicto Santiago, when they were both sixteen. They later had a second child two years later, named Sylvia Santiago. Maria's children, along with her parents, were killed on Emergence Day. That event would lead to her depression and eventual self exile. After years of being missing, she was finally found by her husband and Marcus Fenix in a Locust prison camp only to find that she had been "processed" and severely tortured to the point that she couldn't even recognize her own husband. Dom was forced to euthanize her to end her suffering, something he never recovered from.