Salviana Route 346 begins near the city of Carlisle at National Route 801. From its beginning, State Route 346 runs east through rural Brennazo and Penn counties before reaching the town of Schneitzel. After leaving Schneitzel, Highway 346 crosses the Long River and enters Dreutzel County before entering Berks County and running along the Penoshia state line before ending at National Route 333 just across the Borderline River from the town of Kennaucht, Penoshia.