Charlene Doofenshmirtz is the ex-wife of Dr. Heinz Doofenshmirtz and shares custody of their daughter, Vanessa. She didn't divorce Heinz because he was evil; in her words, they just didn't get along very well and wanted different things. Whenever Vanessa tries to tell her that Heinz is actually evil, Charlene is adamant that no one can be evil. In contrast to Heinz's agitation with her, she is actually very civil in his presence and talks of and to him as if they were still on relatively good terms ("I Scream, You Scream", "Hail Doofania!")