There is a mysterious figure by the name of Edmund Gareth, also known as the Mad Alchemist. Edmund has created a cryptic and deadly tournament called Brutal Fists (hence the game's title) where the best fighters compete against each other. Behind that tournament lies a plot conducted by the Mad Alchemist himself, which is to take over the world with his homunculi army and make himself a god of it. Will a winner defeat the Mad Alchemist and save the world from his coming tyranny?