The sky has important religious significance. Most polytheistic religions have a deity or deities whose portfolio includes or is even limited to the sky or the heavens. While there are often multiple sky deities, sometimes this position is reserved for a deity who is conceived as reigning over the others, or at least is one of the most powerful. When the main sky deity was seen as feminine, she often held the title of the "Queen of Heaven." Ancient sky goddesses who held the title "Queen of Heaven" included Isis, Astarte, Ishtar, and Inanna. (The title was later applied to the Virgin Mary, along with various other features and attributes of ancient pagan goddesses.)