DuBois was born in David, Panama. She previously co-starred opposite Star Trek: The Motion Picture actor Stephen Collins and TNG guest-star Elizabeth Lindsey in the television series Tales of the Gold Monkey, which lasted only one season, airing from September 1982 through June 1983. She also had a recurring role on Magnum, P.I. and made guest appearances on such series as Hardcastle & McCormick (starring Brian Keith and Daniel Hugh Kelly in the title roles), The A-Team (with Dwight Schultz), L.A. Law (starring Corbin Bernsen and Larry Drake), Silk Stalkings, and Matlock.