Isaac Hilton (born February 26, 1981 in Long Beach, California) is an American football defensive lineman. He was drafted out of Hampton University by the New York Giants, but was cut before the beginning of the season. He then played briefly for the Tampa Bay Buccaneers and the Carolina Panthers, and later played for the Arena Football League and Toronto Argonauts. In 2009, while playing for the arenafootball2 Wilkes-Barre/Scranton Pioneers, Hilton was arrested and charged with possession of 70 bags of marijuana with the intent to distribute them.